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Hongzhuan Chen Selected Research

Pilocarpine (Ocusert)

4/2010Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: involvement of muscarinic receptors and HIF-1 alpha pathway.
6/2009Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells.

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Hongzhuan Chen Research Topics

Disease

31Alzheimer Disease (Alzheimer's Disease)
12/2023 - 06/2009
27Neoplasms (Cancer)
04/2024 - 11/2011
9Memory Disorders (Memory Loss)
01/2023 - 03/2014
8Glioma (Gliomas)
08/2023 - 11/2011
7Gliosis
12/2019 - 07/2014
6Neuroinflammatory Diseases
01/2021 - 01/2008
5COVID-19
02/2024 - 07/2020
5Hypoxia (Hypoxemia)
02/2024 - 06/2009
5Glioblastoma (Glioblastoma Multiforme)
02/2024 - 07/2013
5Lung Neoplasms (Lung Cancer)
01/2020 - 01/2015
4Neurodegenerative Diseases (Neurodegenerative Disease)
02/2023 - 06/2009
4Neoplasm Metastasis (Metastasis)
01/2023 - 12/2013
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2019 - 01/2015
3Inflammation (Inflammations)
12/2023 - 01/2018
3Glaucoma
05/2011 - 06/2009
2Central Nervous System Diseases (CNS Diseases)
05/2024 - 11/2008
2Breast Neoplasms (Breast Cancer)
04/2024 - 01/2019
2Parkinson Disease (Parkinson's Disease)
02/2023 - 05/2022
2Pain (Aches)
01/2023 - 11/2005
2Colorectal Neoplasms (Colorectal Cancer)
11/2022 - 01/2022
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2021 - 06/2015
2Ischemic Stroke
12/2019 - 01/2017
2Brain Diseases (Brain Disorder)
01/2019 - 03/2014
2Neuroblastoma
06/2009 - 01/2008
1Pneumonia (Pneumonitis)
12/2023

Drug/Important Bio-Agent (IBA)

15Peptides (Polypeptides)IBA
04/2024 - 06/2009
11Proteins (Proteins, Gene)FDA Link
05/2024 - 06/2009
8Cholinergic Agents (Cholinergics)IBA
11/2019 - 01/2008
7Amyloid beta-PeptidesIBA
02/2023 - 06/2009
7Paclitaxel (Taxol)FDA LinkGeneric
08/2015 - 11/2011
6Amyloid (Amyloid Fibrils)IBA
01/2022 - 09/2014
6AcetylcholinesteraseIBA
01/2019 - 02/2012
6LigandsIBA
08/2015 - 01/2008
5Lipoproteins (Lipoprotein)IBA
02/2024 - 03/2014
5Potassium Channels (Potassium Channel)IBA
10/2017 - 07/2014
5monomethoxypolyethyleneglycol- polylactide block copolymerIBA
09/2014 - 06/2013
4Oxygen (Dioxygen)IBA
02/2024 - 01/2017
3Antiviral Agents (Antivirals)IBA
02/2024 - 07/2020
3CalciumIBA
01/2023 - 01/2018
3Glucose (Dextrose)FDA LinkGeneric
11/2021 - 01/2017
3Acetylcholine (Acetylcholine Chloride)FDA Link
12/2020 - 10/2015
3Neuroprotective AgentsIBA
11/2020 - 11/2012
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019 - 11/2012
3Intermediate-Conductance Calcium-Activated Potassium ChannelsIBA
10/2016 - 07/2014
3Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
01/2015 - 06/2009
3cobaltous chloride (cobalt(II)chloride)IBA
11/2012 - 06/2009
2Peptide Hydrolases (Proteases)FDA Link
02/2024 - 01/2021
2Therapeutic UsesIBA
12/2023 - 03/2020
2LipopolysaccharidesIBA
12/2023 - 12/2019
2mangostinIBA
02/2023 - 03/2016
2SynucleinsIBA
02/2023 - 05/2022
2Cell-Penetrating PeptidesIBA
01/2023 - 03/2013
2EnzymesIBA
01/2023 - 10/2021
2CytokinesIBA
01/2023 - 01/2022
2Small Interfering RNA (siRNA)IBA
01/2023 - 01/2015
22-mercaptopurineIBA
01/2021 - 06/2015
2Glutamic Acid (Glutamate)FDA Link
11/2020 - 11/2015
2MicroRNAs (MicroRNA)IBA
03/2020 - 01/2018
2Insulin (Novolin)FDA Link
12/2019 - 01/2019
2Gefitinib (Iressa)FDA Link
01/2019 - 01/2018
2ErbB Receptors (EGF Receptor)IBA
01/2018 - 11/2017
2Tyrosine Kinase InhibitorsIBA
01/2018 - 11/2017
2Glial Fibrillary Acidic ProteinIBA
01/2017 - 07/2014
2SolutionsIBA
11/2015 - 07/2013
2Muscarinic M2 ReceptorIBA
10/2015 - 01/2015
2Transferrin (beta 2 Transferrin)IBA
08/2015 - 06/2013
2NeurotoxinsIBA
04/2015 - 01/2008
2polyethylene glycol-poly(lactide-co-glycolide)IBA
05/2014 - 11/2011
2Matrix Metalloproteinases (MMPs)IBA
07/2013 - 03/2013
2Pilocarpine (Ocusert)FDA LinkGeneric
04/2010 - 06/2009
2PMS 777IBA
06/2009 - 01/2008
1Fatty Acids (Saturated Fatty Acids)IBA
04/2024
1Orphan Nuclear ReceptorsIBA
04/2024
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
04/2024
1Antineoplastic Agents (Antineoplastics)IBA
04/2024
1Protein Tyrosine PhosphatasesIBA
04/2024
1Tyrosine (L-Tyrosine)FDA Link
04/2024
1Rosmarinic AcidIBA
02/2024
1calcium peroxideIBA
02/2024
1PorphyrinsIBA
02/2024
11-phenyl-3,3-dimethyltriazene (PDT)IBA
02/2024
1Phosphotransferases (Kinase)IBA
01/2024
1HydrogelsIBA
12/2023
1Ginkgo biloba extract (Rokan)IBA
12/2023
13,4-dihydroxyphenyllactic acidIBA
12/2023
1FluorineIBA
09/2023
1cadherin 5IBA
08/2023
1Angiotensin-Converting Enzyme 2IBA
01/2023
1AntioxidantsIBA
01/2023
1MagnesiumIBA
01/2023
1MeptazinolIBA
01/2023
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2023

Therapy/Procedure

24Therapeutics
05/2024 - 05/2011
6Immunotherapy
01/2023 - 01/2018
4Drug Therapy (Chemotherapy)
01/2023 - 09/2014
3Chinese Traditional Medicine (Traditional Chinese Medicine)
02/2024 - 10/2020
3Intranasal Administration
12/2023 - 02/2012
2Intravenous Administration
09/2014 - 05/2014
1Photochemotherapy (Photodynamic Therapy)
02/2024
1Transplantation
08/2023